 Hydergine stimulates oxygen flow to the brain, relieving symptoms of deteriorating mental capacity
Currently Hydergine is used almost exclusively for treating patients with either dementia, or 'age-related' cognitive symptoms.
Hydergine is a popular "smart pill" because it works in several ways to improve memory and mental function and protect the brain from aging-related damage. People routinely use Hydergine as a productivity enhancing drug. In emergencies, doctors inject Hydergine directly into the carotid artery to protect the brain. Hydergine's mechanisms of actions include the reduction in the rate of lipofuscin deposition in brain cells, increased metabolism of brain cells by improving ATP synthesis and protection to the brain from free radical damage.
Many life extension physicians and enthusiasts first learned of the concept of “smart drugs” from reading the best-selling book, Life Extension, A Practical Scientific Approach, by Durk Pearson and Sandy Shaw. Pearson and Shaw extolled the virtues of a drug called Hydergine- a Novartis trademark (ergoloid mesylates), a combination of three ergot alkaloids.
They reported that Novartis Pharmaceuticals claimed Hydergine was the “most intensively studied drug in the world” and at the time they wrote their book it was “the fifth best selling drug in the world.”
Hydergine was originally developed as an anti-hypertensive medication, but it was soon found that it really wasn't very effective in reducing elevated blood pressure. However, a number of people who used it did report improvements in memory, mood and overall sense of well being. At first, it was believed that these effects were due to increased cerebral blood flow. Later, however, it was determined that Hydergine actually acted to improve brain cell metabolism in a number of ways.
Hydergine increases stores of the universal energy molecule, adenosine triphosphate (ATP), stabilises the intracellular messenger molecule cyclic adenosine monophosphate (cAMP) content of nerve cells, improves utilization of glucose in the brain, and enhances cerebral microcirculation.
There has been a vast amount of research conducted with Hydergine, and its enviable record of near-absolute safety.
One of the 'believed-to-be-inevitable' consequences of aging, is a decrease in the number of synapses- i.e., connections between brain cells. This decrease of brain cell to brain cell connection has been hypothesised to be due to impairment in the energy supply at synaptic regions.
Because of Hydergine's known ability to improve nerve cell metabolism, a group of Italian scientists studied the ultrastructural features of synaptic mitochondria of the brain cells of rats of different ages, to determine if long-term Hydergine treatment could prevent or delay the loss of synaptic connections.
The mitochondria, remember, are the “intracellular powerhouses” where the universal energy molecule- adenosine triphosphate (ATP) is produced. Using a computer assisted image analyzer, the researchers measured three mitochondrial parameters, volume density, Vv, the fraction of the cell volume occupied by the mitochondria, numerical density, Nv, the number of mitochondria per cubic micrometer and average size, Sk, mitochondrial skeletal length.
They found that the number of mitochondria is greatest at about 12 months of age in rats, (the equivalent of a human 25-year-old), and then progressively decreases.
The size of the mitochondria, however, increased progressively after 12 months, in an apparent effort to compensate for the reduction in the number and efficiency of energy producing mitochondria. Because of this reciprocal relationship between mitochondrial size and number, there was little change in the overall total volume of mitochondria per cell.
Thus in young adult animals, the energy required at synaptic regions is provided by a large number of small, highly efficient mitochondria, whereas in old animals, energy is produced by a smaller number of larger, less efficient mitochondria.
Unfortunately, despite their larger size, because of decreased functionality of a number of mitochondrial enzymes, the few enlarged mitochondria tend to be less able to accomplish their tasks, especially when there is a high demand for energy.
After treatment with Hydergine, it can be seen that the total mitochondrial volume of old rats was nearly the same as the young adults, and the number and mitochondrial size was altered in a more youthful direction
The above combined clinical and laboratory data support the recommendation of many anti-aging physicians that Hydergine should continue to be incorporated in an anti-aging/ smart drug regimen.
Dosage: The approved recommended dosage in the US remains 3mg per day.
Safety: Persons taking prescription medication and pregnant or lactating women should consult a physician before using this product. Long-term use of this product should be supervised and monitored by a health care professional.
Disclaimer: This product and its statements have not been evaluated by the FDA. This product is not intended to treat, cure or prevent any disease. The above information is provided under the supplying company's terms and conditions and should not replace the advice of your personal physician.
Restrictions: This product is not available for shipment to the EU
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