GHRP6 is a peptide that is a member of the growth factor family, it is a derivative of Ghrelin, (an acronym for Growth Hormone Release Inducing); which in turn is a hormone that is released in response to hunger- which naturally creates the desire to eat.
However, the GHRP6 (just like the GHRP2 version- see Q&A’s below), does not induce the kind of desire to eat that Ghrelin itself does. However, just like Ghrelin, GHRP6 can be used to treat growth hormone deficiency, a problem that is well known in the antiaging fraternity and can affect many persons over the age of 35.
GHRP6 works by signalling the pituitary gland to begin growth hormone (GH) secretion and therefore is classed as a secretagogue.
GH and its by-product IGF-1, (insulin like growth factor, which is produced in the liver by GH in the blood) are desired by those who want to improve their physique. GH has long been known to improve the ratio of fat to muscle, although the actual action of instructing the cell to stop storing fat and start burning it is likely to be better related to IGF-1.
The problem with GH treatment has been that it has to be administered by injection to be effective; furthermore it is expensive and relatively unstable at anything over room temperature, plus in some countries GH is even listed as a controlled substance.
The work of Dr Richard Walker, (his articles and videos are available via the IAS website), also indicates that injecting GH in bolus form is not bioidentical, whereas GHRP’s tend to amplify the natural increases of GH and therefore represent a safer, (if a little slower) approach to improve GH levels.
When GHRP6 is used it can trigger some response to promote food intake, ergo stimulating some hunger to aid energy metabolism. This tends to happen within 15-30 minutes of applying the nasal spray. In this way GHRP6 can be considered to be a good aid to help treat eating disorders such as anorexia and also cachexia, (a wasting disorder).
Despite this, body shape is improved, for whilst ‘body mass’ may be increased, the vast amount is muscle rather than fat, so as GHRP6 increases body weight, in turn there is better shape and tone to the body because of the enhanced muscle content.
There is some evidence to suggest that the GHRP6 version has more affinity to increase IGF-1 levels than other GHRP’s. Therefore this has significance for increasing the strength of muscles, bones and joints in individuals.
Typical doses are 1 spray into each nostril (10 IU each) once or twice daily. The doses may be best served early morning (when GH levels are highest) and again at bedtime to induce GH levels during REM sleep.
Side effects and overdosing are the same as GH and blood measurement for IGF-1 is recommended for long term use- to ensure that they remain within normal ‘youthful’ levels.
Questions and Answers
Q. “What is the difference between GHRP2 and GHRP6? When should I use one over the other?”
A. “Both are derivatives of Ghrelin, but we have noted that GHRP2 appears to have less hunger feelings after use than GHRP6. As such, we feel that GHRP2 may be better suited to people who want to lose weight and GHRP6 may be better suited to those who want to increase their muscle mass- which by definition means increasing body weight.”
Q. “How many milligrams and sprays are in each 5ml bottle?”
A. “Each bottle has 50 sprays and a total of 25 mg. Each spray is 10 IU and therefore each spray contains 0.5 mg of GHRP6.”
Chemical: GHRP6 (growth hormone releasing peptide 6 secretagogue)
Ingredients: 5 ml solution with a total of 500 IUs (International Units)
Properties: GHRP6 stimulates the release of growth hormone (GH), a 191 amino acid polypeptide, and consequently, it stimulates growth, cell reproduction and most importantly, regeneration in humans and other animals. The anterior pituitary gland synthesizes and releases GH in a pulsatile manner, in response to these stimuli by the hypothalamus or externally with nasal spray administration of GHRP6. The largest and most predictable of these GH peaks occurs about an hour after onset of sleep with plasma levels of 13 to 72 ng/mL. Otherwise there is wide variation between days and individuals. Nearly fifty percent of GH secretion occurs during the third and fourth REM sleep stages. Surges of secretion during the day occur at 3- to 5-hour intervals. The plasma concentration of GH during these peaks may range from 5 to even 45 ng/mL. Between the peaks, basal GH levels are low, usually less than 5 ng/mL for most of the day and night.
A number of factors are known to affect GH secretion, such as age, sex, diet, exercise, stress, and other hormones. Young adolescents secrete GH at the rate of about 700 Î¼g/day, while healthy adults secrete GH at the rate of about 400 Î¼g/day. Sleep deprivation generally suppresses GH release, particularly after early adulthood. Adults with GH deficiency have a relative increase in fat mass and a relative decrease in muscle mass and, in many instances, decreased energy and quality of life. Claims for GH as an anti-aging treatment date back to 1990 when the New England Journal of Medicine published a study wherein GH was used to treat 12 men over 60 years of age. All the men showed statistically significant increases in lean body mass and bone mineral density, while the control group did not. The authors of the study noted that these improvements were the opposite of the changes that would normally occur over a 10- to 20-year aging period.
Directions: Apply one spray into the nose, once or twice daily (each spray is 10 IU) or as directed by your physician. The maximum daily allowance for adults is 100 IU. The maximum dosage to be given at a one time is 20 IU.
Caution: Do not use with alcohol.
Contraindications and interactions: GHRP6 and its downstream hormone, hGH is incompatible with ethanol use.
Side Effects: GH is produced by a secretagogue, GHRP6, and it has acceptable safety in light of its benefits. There are several possible side effects caused by GH. Rarely, patients can experience joint swelling, joint pain, carpal tunnel syndrome, and an increased risk of diabetes. In some cases, the patient can produce an immune response against GH. GH may also be a risk factor for Hodgkin’s lymphoma. One survey of adults that had been treated with replacement cadaver GH (which has not been used anywhere in the world since 1985) during childhood showed a mildly increased incidence of colon cancer and prostate cancer, but linkage with the GH treatment was not established.
Intoxication and its treatment: No known intoxication except when used simultaneously with alcohol consumption. Avoid ethanol and all forms of alcoholic beverage.
Presentation and use: 5 ml spray bottle. (1) Remove cap and squeeze 3 times before the first spray. (2) Introduce the spray bottle vertically into one nostril and squeeze once. Repeat with the other nostril. The patient should then inhale gently. (3) Replace cap after use.
Storage: The preparation may be kept at room temperature providing it is in a cool and dry place out of sunlight; else it should be kept in the cooler part of a fridge (i.e. the door). Once opened use and discard after a month or two.
Precautions: Keep this and all other medicines out of the reach of children. This product is not intended for use by pregnant or lactating women. This information does not replace your physician’s advice, always seek and follow your physician’s advice.