(US) $29.99


Re-boot your brain with SAMe antidepressant supplement

SAMe is a natural energy-enhancing chemical which has become one of the most sought-after treatments for depression in recent history. Often referred to as the day-time alertness hormone, SAMe antidepressant medication is known to improve brain power and reduce stress, as well as relieving anxiety and depression.

SAMe is a powerful antidepressant supplement which has none of the unwelcome side effects associated with other antidepression medicine. It works by enhancing the impact of mood-boosting neurotransmitters, such as serotonin and dopamine. SAMe antidepressant supplements perform just as well as more traditional treatments for depression yet they are completely natural.

Not only is SAMe natural antidepressant medication as effective and less toxic in treating depression than any other antidepressant supplement, its benefits are far more rapid. Whereas most traditional treatments for depression take 3-4 weeks before taking effect, SAMe natural depression treatment starts to work after just a few days.

What is SAMe?

SAMe is a naturally occurring molecule that is produced constantly by all living cells. Its full chemical name is S-adenosyl-L-methionine and it’s sold under the brand name Samyr400. Samyr400 pills are enteric coated to stop their S-adenosyl-L-methionine content from being destroyed by the stomach and digested by the small intestine instead.

S-adenosyl-L-methionine plays an essential role in energising chemical processes throughout the body. It is particularly important in the production of adenosine triphosphate (ATP) which is one of the most fundamental, ‘energy of life’ biomolecules.

SAMe is also closely correlated with Melatonin the sleep hormone. When Melatonin levels are low, SAMe levels are high and vice versa. SAMe is often described as the day-time alertness hormone, just as Melatonin is referred to as the hormone of sleep.

S-adenosyl-L-methionine is highly concentrated in the liver, so in addition to its use as a depression treatment it’s one of the most widely-used liver drug treatments around. SAMe tablets are frequently used as liver drug treatments for conditions such as cirrhosis and even hepatitis.

How does SAMe work as an antidepressant?

SAMe natural depression treatment has been hailed as the safest and most effective natural antidepression medicine available without prescription. SAMe antidepression medicine is derived from a combination of two molecules – methionine and adenosine triphosphate (ATP).

SAMe acts as a methylating agent in the brain, providing essential methyl groups to proteins, DNA and other molecules. Methyl group deficiency is a contributing factor to depression and other brain diseases. Methylation is a crucial process for maintaining good brain health and keeping depression at bay.

Methylation occurs billions of times a second throughout our bodies. It’s a constant process of recycling and rejuvenation. Although there are other chemicals that act as methyl donors, SAMe is the most active. Without it there would be no methylation – and therefore no life as we know it.

SAMe depression treatment tablets work by boosting the effectiveness of neurotransmitters, such as dopamine and serotonin. They increase brain power and reduce stress, making SAMe an extremely effective depression treatment. SAMe antidepression medicine also has antioxidant properties, which enhances its natural antidepressant properties.

SAMe was discovered back in the 1950s although a pharmaceutical version was not developed until the 1970s. It has been the subject of numerous trials throughout Europe involving thousands of patients. The conclusion of all this research being that SAMe performs equally efficiently as more traditional antidepressant treatments, without any of the adverse side effects.

How should SAMe be taken as an antidepressant supplement? Whether SAMe antidepression medication is being taken for depression in man or depression in woman, the prescription is the same. As an antidepressant supplement, and to reduce stress, the dosage is 800 to 2000mg daily.

Just as Melatonin is often prescribed as the hormone of sleep, SAMe antidepression medicine will improve day-time alertness and reduce stress thereby delivering a powerful dose of SAMe alertness and antidepressant properties.


SAMe is a natural energy-enhancing agent which has become one of the most sought-after treatments for well-being. It has so many benefits because it assists the body as a methylation agent, helping to convert the hormones the body needs.


Take one or two tablets daily, preferably on an empty stomach with water. Always follow your physician’s advice.


Keep in cool dark conditions, out of the reach of children and consume before end of expiry date. Not for use by pregnant or lactating women.


This product and its statements have not been evaluated  by the FDA. This product is not intended to treat, cure or prevent any disease.

Suitable For Vegetarians

Supplement Facts:

Serving size: 1 tablet

Servings per container: 20

S-Adenosyl-L-Methionine 400mg

Other ingredients:

Microcrystalline cellulose, magnesium stearate, polyethylene glycol 6000, polymethacrylate, polysorbate, colloidal silica, emulsied silicone, sodium starch glycolate, talc.